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Calibrating Critical Sensors in Depyrogenation Tunnels

Monday, September 14, 2020

Allerød, Denmark – Pharmaceutical labs wage a constant battle with bacterial pathogens and other contaminants that may compromise the drugs and medicines they produce. Of particular concern are bacterial pyrogens, which, when present, can cause a fever. As traditional sterilization techniques are not effective on these tiny organisms, labs employ Depyrogenation (or Dry Heat Sterilization) to ensure that their solutions and surfaces are free of the bacteria.

Depyrogenation uses air temperatures exceeding 350°C (600°F) to burn away the bacterial pyrogens. Super-hot ovens, called Depyrogenation Tunnels, are used to generate the necessary heat. Each sterilization zone within the Tunnel contains critical temperature sensors. These sensors undergo regular temperature calibration to ensure they are functioning correctly and meet regulatory requirements.

With their absence of liquid - removing the potential for spillage and contamination – the JOFRA PTC dry-block temperature calibrators provide an ideal means of calibrating these all-important sensors.

JOFRA offers five PTC Series models delivering temperature ranges from -90°C / -130°F up to 660°C /1220°F. All models feature high accuracy, stability, and speed; and an active dual-zone temperature control, which delivers excellent temperature homogeneity in the well. The easy to read color display and intuitive, user-friendly navigation reduce training time and errors.


AMETEK STC manufactures and supplies calibration instruments for temperature, pressure, and process signals under the brands JOFRA and Crystal. JOFRA temperature calibrators are known worldwide for their accuracy, stability, and reliability.

See how the JOFRA PTC-425  is the perfect calibrator for the job - Application Note.